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The Use of Phage Cocktail and Various Antibacterial Agents in Combination to Prevent the Emergence of Phage Resistance
Bacterial food poisoning cases due to Salmonella and E. coli O157:H7 have been linked with the consumption of a variety of food products, threatening public health around the world. This study describes the combined effects of a phage cocktail (STG2, SEG5, and PS5), EDTA, nisin, and polylysine again...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295611/ https://www.ncbi.nlm.nih.gov/pubmed/37370397 http://dx.doi.org/10.3390/antibiotics12061077 |
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author | Duc, Hoang Minh Zhang, Yu Hoang, Son Minh Masuda, Yoshimitsu Honjoh, Ken-Ichi Miyamoto, Takahisa |
author_facet | Duc, Hoang Minh Zhang, Yu Hoang, Son Minh Masuda, Yoshimitsu Honjoh, Ken-Ichi Miyamoto, Takahisa |
author_sort | Duc, Hoang Minh |
collection | PubMed |
description | Bacterial food poisoning cases due to Salmonella and E. coli O157:H7 have been linked with the consumption of a variety of food products, threatening public health around the world. This study describes the combined effects of a phage cocktail (STG2, SEG5, and PS5), EDTA, nisin, and polylysine against the bacterial cocktail consisting of S. typhimurium, S. enteritidis, and E. coli O157:H7. Overall, phage cocktail (alone or in combination with nisin or/and polylysine) not only showed great antibacterial effects against bacterial cocktail at different temperatures (4 °C, 24 °C, and 37 °C), but also totally inhibited the emergence of phage resistance during the incubation period. These results suggest that the combination of phages with nisin or/and polylysine has great potential to simultaneously control S. typhimurium, S. enteritidis, and E. coli O157:H7. |
format | Online Article Text |
id | pubmed-10295611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102956112023-06-28 The Use of Phage Cocktail and Various Antibacterial Agents in Combination to Prevent the Emergence of Phage Resistance Duc, Hoang Minh Zhang, Yu Hoang, Son Minh Masuda, Yoshimitsu Honjoh, Ken-Ichi Miyamoto, Takahisa Antibiotics (Basel) Communication Bacterial food poisoning cases due to Salmonella and E. coli O157:H7 have been linked with the consumption of a variety of food products, threatening public health around the world. This study describes the combined effects of a phage cocktail (STG2, SEG5, and PS5), EDTA, nisin, and polylysine against the bacterial cocktail consisting of S. typhimurium, S. enteritidis, and E. coli O157:H7. Overall, phage cocktail (alone or in combination with nisin or/and polylysine) not only showed great antibacterial effects against bacterial cocktail at different temperatures (4 °C, 24 °C, and 37 °C), but also totally inhibited the emergence of phage resistance during the incubation period. These results suggest that the combination of phages with nisin or/and polylysine has great potential to simultaneously control S. typhimurium, S. enteritidis, and E. coli O157:H7. MDPI 2023-06-20 /pmc/articles/PMC10295611/ /pubmed/37370397 http://dx.doi.org/10.3390/antibiotics12061077 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Duc, Hoang Minh Zhang, Yu Hoang, Son Minh Masuda, Yoshimitsu Honjoh, Ken-Ichi Miyamoto, Takahisa The Use of Phage Cocktail and Various Antibacterial Agents in Combination to Prevent the Emergence of Phage Resistance |
title | The Use of Phage Cocktail and Various Antibacterial Agents in Combination to Prevent the Emergence of Phage Resistance |
title_full | The Use of Phage Cocktail and Various Antibacterial Agents in Combination to Prevent the Emergence of Phage Resistance |
title_fullStr | The Use of Phage Cocktail and Various Antibacterial Agents in Combination to Prevent the Emergence of Phage Resistance |
title_full_unstemmed | The Use of Phage Cocktail and Various Antibacterial Agents in Combination to Prevent the Emergence of Phage Resistance |
title_short | The Use of Phage Cocktail and Various Antibacterial Agents in Combination to Prevent the Emergence of Phage Resistance |
title_sort | use of phage cocktail and various antibacterial agents in combination to prevent the emergence of phage resistance |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295611/ https://www.ncbi.nlm.nih.gov/pubmed/37370397 http://dx.doi.org/10.3390/antibiotics12061077 |
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