Sirtuin Inhibitor Cambinol Induces Cell Differentiation and Differently Interferes with SIRT1 and 2 at the Substrate Binding Site

Epigenetic mechanisms finely regulate gene expression and represent potential therapeutic targets. Cambinol is a synthetic heterocyclic compound that inhibits class III histone deacetylases known as sirtuins (SIRTs). The acetylating action that results could be crucial in modulating cellular functio...

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Detalles Bibliográficos
Autores principales: Giordano, Deborah, Scafuri, Bernardina, De Masi, Luigi, Capasso, Lucia, Maresca, Viviana, Altucci, Lucia, Nebbioso, Angela, Facchiano, Angelo, Bontempo, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295654/
https://www.ncbi.nlm.nih.gov/pubmed/37371719
http://dx.doi.org/10.3390/biomedicines11061624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295654/
https://www.ncbi.nlm.nih.gov/pubmed/37371719
http://dx.doi.org/10.3390/biomedicines11061624

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