The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

Increased oxidative stress, dysfunctional cellular clearance, and chronic inflammation are associated with age-related macular degeneration (AMD). Prolyl oligopeptidase (PREP) is a serine protease that has numerous cellular functions, including the regulation of oxidative stress, protein aggregation...

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Detalles Bibliográficos
Autores principales: Toppila, Maija, Hytti, Maria, Korhonen, Eveliina, Ranta-aho, Sofia, Harju, Niina, Forsberg, Markus M., Kaarniranta, Kai, Jalkanen, Aaro, Kauppinen, Anu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295660/
https://www.ncbi.nlm.nih.gov/pubmed/37372009
http://dx.doi.org/10.3390/antiox12061279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295660/
https://www.ncbi.nlm.nih.gov/pubmed/37372009
http://dx.doi.org/10.3390/antiox12061279

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