Adjuvant Therapy with Oncolytic Adenovirus Delta-24-RGDOX After Intratumoral Adoptive T-cell Therapy Promotes Antigen Spread to Sustain Systemic Antitumor Immunity

Cancer cell heterogeneity and immunosuppressive tumor microenvironment (TME) pose a challenge in treating solid tumors with adoptive cell therapies targeting limited tumor-associated antigens (TAA), such as chimeric antigen receptor T-cell therapy. We hypothesize that oncolytic adenovirus Delta-24-R...

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Detalles Bibliográficos
Autores principales: Jiang, Hong, Shin, Dong Ho, Yi, Yanhua, Fan, Xuejun, Gumin, Joy, He, Jiasen, Gillard, Andrew G., Lang, Frederick F., Gomez-Manzano, Candelaria, Fueyo, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295804/
https://www.ncbi.nlm.nih.gov/pubmed/37379361
http://dx.doi.org/10.1158/2767-9764.CRC-23-0054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295804/
https://www.ncbi.nlm.nih.gov/pubmed/37379361
http://dx.doi.org/10.1158/2767-9764.CRC-23-0054

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