Targeting Mitochondrial DNA Transcription by POLRMT Inhibition or Depletion as a Potential Strategy for Cancer Treatment

Transcription of the mitochondrial genome is essential for the maintenance of oxidative phosphorylation (OXPHOS) and other functions directly related to this unique genome. Considerable evidence suggests that mitochondrial transcription is dysregulated in cancer and cancer metastasis and contributes...

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Detalles Bibliográficos
Autores principales: Daglish, Sabrina C. D., Fennell, Emily M. J., Graves, Lee M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295849/
https://www.ncbi.nlm.nih.gov/pubmed/37371693
http://dx.doi.org/10.3390/biomedicines11061598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295849/
https://www.ncbi.nlm.nih.gov/pubmed/37371693
http://dx.doi.org/10.3390/biomedicines11061598

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