Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine

Opioid analgesics such as morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Herein, we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using (35)S-GTPγS binding assays. While all of the agonists act...

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Detalles Bibliográficos
Autores principales: Acevedo-Canabal, Agnes, Grim, Travis W., Schmid, Cullen L., McFague, Nina, Stahl, Edward L., Kennedy, Nicole M., Bannister, Thomas D., Bohn, Laura M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295947/
https://www.ncbi.nlm.nih.gov/pubmed/37371516
http://dx.doi.org/10.3390/biom13060935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295947/
https://www.ncbi.nlm.nih.gov/pubmed/37371516
http://dx.doi.org/10.3390/biom13060935

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