CD28 and 41BB Costimulatory Domains Alone or in Combination Differentially Influence Cell Surface Dynamics and Organization of Chimeric Antigen Receptors and Early Activation of CAR T Cells

SIMPLE SUMMARY: Chimeric antigen receptor (CAR)-modified T cells have revolutionized the treatment of chemotherapy-resistant lymphomas, but CAR T cell therapy for solid tumors has been disappointing. This study examined the molecular structure, membrane organization, and mobility of HER2-specific CA...

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Detalles Bibliográficos
Autores principales: Mezősi-Csaplár, Marianna, Szöőr, Árpád, Vereb, György
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295952/
https://www.ncbi.nlm.nih.gov/pubmed/37370693
http://dx.doi.org/10.3390/cancers15123081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295952/
https://www.ncbi.nlm.nih.gov/pubmed/37370693
http://dx.doi.org/10.3390/cancers15123081

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