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CD28 and 41BB Costimulatory Domains Alone or in Combination Differentially Influence Cell Surface Dynamics and Organization of Chimeric Antigen Receptors and Early Activation of CAR T Cells

SIMPLE SUMMARY: Chimeric antigen receptor (CAR)-modified T cells have revolutionized the treatment of chemotherapy-resistant lymphomas, but CAR T cell therapy for solid tumors has been disappointing. This study examined the molecular structure, membrane organization, and mobility of HER2-specific CA...

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Detalles Bibliográficos
Autores principales:	Mezősi-Csaplár, Marianna, Szöőr, Árpád, Vereb, György
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295952/ https://www.ncbi.nlm.nih.gov/pubmed/37370693 http://dx.doi.org/10.3390/cancers15123081

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