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TLR7 Agonist GS–9620 Combined with Nicotinamide Generate Viral Reactivation in Seronegative SHIV(SF162P3)-Infected Rhesus Monkeys

Antiretroviral therapy is capable of inhibiting HIV replication, but it fails to completely achieve a cure due to HIV persistence. The commonly used HIV cure approach is the “shock and kill” strategy, which employs latency-reversing agents to trigger viral reactivation and boost cellular immunity. F...

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Detalles Bibliográficos
Autores principales: Cong, Zhe, Sun, Yuting, Dang, Cui, Yang, Chenbo, Zhang, Jingjing, Lu, Jiahan, Chen, Ting, Wei, Qiang, Wang, Wei, Xue, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295986/
https://www.ncbi.nlm.nih.gov/pubmed/37371802
http://dx.doi.org/10.3390/biomedicines11061707