Inhibition of the Mitochondrial Carnitine/Acylcarnitine Carrier by Itaconate through Irreversible Binding to Cysteine 136: Possible Pathophysiological Implications

Background: The carnitine/acylcarnitine carrier (CAC) represents the route of delivering acyl moieties to the mitochondrial matrix for accomplishing the fatty acid β-oxidation. The CAC has a couple of Cys residues (C136 and C155) most reactive toward ROS and redox signaling compounds such as GSH, NO...

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Detalles Bibliográficos
Autores principales: Giangregorio, Nicola, Tonazzi, Annamaria, Console, Lara, Scalise, Mariafrancesca, Indiveri, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296061/
https://www.ncbi.nlm.nih.gov/pubmed/37371573
http://dx.doi.org/10.3390/biom13060993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296061/
https://www.ncbi.nlm.nih.gov/pubmed/37371573
http://dx.doi.org/10.3390/biom13060993

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