Bone Marrow Microenvironment-Induced Chemoprotection in KMT2A Rearranged Pediatric AML Is Overcome by Azacitidine–Panobinostat Combination

SIMPLE SUMMARY: Leukemic cells evade chemotherapy due to interactions within the bone marrow microenvironment. We have tested the effect of epigenetic therapy on pediatric AML cells in multicell coculture and in murine models. Epigenetic drug combination followed by chemotherapy was effective in ove...

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Detalles Bibliográficos
Autores principales: Lehner, Kara M., Gopalakrishnapillai, Anilkumar, Kolb, Edward Anders, Barwe, Sonali P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296268/
https://www.ncbi.nlm.nih.gov/pubmed/37370721
http://dx.doi.org/10.3390/cancers15123112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296268/
https://www.ncbi.nlm.nih.gov/pubmed/37370721
http://dx.doi.org/10.3390/cancers15123112

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