Identification of the Stapled α-Helical Peptide ATSP-7041 as a Substrate and Strong Inhibitor of OATP1B1 In Vitro

ATSP-7041, a stapled α-helical peptide that inhibits murine double minute-2 (MDM2) and MDMX activities, is a promising modality targeting protein–protein interactions. As peptides of molecular weights over 1000 Da are not usually evaluated, data on the drug–drug interaction (DDI) potential of staple...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishikawa, Rika, Saito, Kosuke, Misawa, Takashi, Demizu, Yosuke, Saito, Yoshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296347/
https://www.ncbi.nlm.nih.gov/pubmed/37371582
http://dx.doi.org/10.3390/biom13061002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296347/
https://www.ncbi.nlm.nih.gov/pubmed/37371582
http://dx.doi.org/10.3390/biom13061002

Ejemplares similares