Disease-Specific α-Synuclein Seeding in Lewy Body Disease and Multiple System Atrophy Are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain

Recent studies have been able to detect α-synuclein (αSyn) seeding in formaldehyde-fixed paraffin-embedded (FFPE) tissues from patients with synucleinopathies using seed amplification assays (SAAs), but with relatively low sensitivity due to limited protein extraction efficiency. With the aim of int...

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Detalles Bibliográficos
Autores principales: Kim, Ain, Martinez-Valbuena, Ivan, Li, Jun, Lang, Anthony E., Kovacs, Gabor G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296376/
https://www.ncbi.nlm.nih.gov/pubmed/37371515
http://dx.doi.org/10.3390/biom13060936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296376/
https://www.ncbi.nlm.nih.gov/pubmed/37371515
http://dx.doi.org/10.3390/biom13060936

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