Cargando…

Spatial Heterogeneity in Cytoskeletal Mechanics Response to TGF-β1 and Hypoxia Mediates Partial Epithelial-to-Meshenchymal Transition in Epithelial Ovarian Cancer Cells

SIMPLE SUMMARY: One major challenge to understanding and targeting deadly epithelial ovarian cancer is the heterogeneous nature of the disease, including intrinsic physical and genetic differences in cells and differences in the spatial microenvironmental cues in the tumor. In this study, we show th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghosh, Deepraj, Hsu, Jeffrey, Soriano, Kylen, Peña, Carolina Mejia, Lee, Amy H., Dizon, Don S., Dawson, Michelle R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296400/ https://www.ncbi.nlm.nih.gov/pubmed/37370796 http://dx.doi.org/10.3390/cancers15123186

Ejemplares similares

Metronomic and single high-dose paclitaxel treatments produce distinct heterogenous chemoresistant cancer cell populations
por: Mejia Peña, Carolina, et al.
Publicado: (2023)

Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells
por: Xuan, Botai, et al.
Publicado: (2018)

TGF-β1 Pretreatment Improves the Function of Mesenchymal Stem Cells in the Wound Bed
por: Ghosh, Deepraj, et al.
Publicado: (2017)

Epigenetic regulation of epithelial-mesenchymal transition: focusing on hypoxia and TGF-β signaling
por: Lin, Yueh-Te, et al.
Publicado: (2020)

Rapid Cytoskeletal Response of Epithelial Cells to Force Generation by Type IV Pili
por: Opitz, Dirk, et al.
Publicado: (2011)

HIF stabilization inhibits renal epithelial cell migration and is associated with cytoskeletal alterations
por: Müller, Simon, et al.
Publicado: (2018)

Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis
por: Datta, Arpita, et al.
Publicado: (2021)

Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets
por: Prechova, Magdalena, et al.
Publicado: (2022)

Epithelial RAC1 niches in IBD: from barrier integrity to cytoskeletal plasticity
por: Haag, Lea-Maxie, et al.
Publicado: (2023)

Regulation of Intestinal Epithelial Cell Cytoskeletal Remodeling by Cellular Immunity Following Gut Infection
por: Solaymani-Mohammadi, Shahram, et al.
Publicado: (2012)

Cytoskeletal changes induced by allosteric modulators of calcium-sensing receptor in esophageal epithelial cells
por: Abdulnour-Nakhoul, Solange, et al.
Publicado: (2015)

Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract
por: Morris, H T, et al.
Publicado: (2015)

Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis
por: Turkel, Nezaket, et al.
Publicado: (2015)

Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity
por: Lachowicz-Scroggins, Marrah E., et al.
Publicado: (2018)

Electrochemical gradients are involved in regulating cytoskeletal patterns during epithelial morphogenesis in the Drosophila ovary
por: Weiß, Isabel, et al.
Publicado: (2019)

Epithelial cells sense local stiffness via Piezo1 mediated cytoskeletal reorganization
por: Jetta, Deekshitha, et al.
Publicado: (2023)

Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1
por: Påhlman, Lisa I, et al.
Publicado: (2015)

Cofilin 1 induces the epithelial-mesenchymal transition of gastric cancer cells by promoting cytoskeletal rearrangement
por: Wang, Haibo, et al.
Publicado: (2017)

Doxycycline Hydrochloride Regulates Cytoskeletal Rearrangement and Epithelial-To-Mesenchymal Transition in Malignant Rhabdoid Tumour of the Kidney
por: Zhanghuang, Chenghao, et al.
Publicado: (2022)

Heterogeneity and plasticity of epithelial–mesenchymal transition (EMT) in cancer metastasis: Focusing on partial EMT and regulatory mechanisms
por: Li, Dandan, et al.
Publicado: (2023)

Partially Evoked Epithelial-Mesenchymal Transition (EMT) Is Associated with Increased TGFβ Signaling within Lesional Scleroderma Skin
por: Nikitorowicz-Buniak, Joanna, et al.
Publicado: (2015)

TWEAK enhances TGF-β-induced epithelial-mesenchymal transition in human bronchial epithelial cells
por: Itoigawa, Yukinari, et al.
Publicado: (2015)

Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells
por: Li, Jingpei, et al.
Publicado: (2020)

Metabolic Reprogramming of Mammary Epithelial Cells during TGF-β-Induced Epithelial-to-Mesenchymal Transition
por: Hua, Wan, et al.
Publicado: (2021)

DNMTs Are Involved in TGF-β1-Induced Epithelial–Mesenchymal Transitions in Airway Epithelial Cells
por: Park, Joo-Hoo, et al.
Publicado: (2022)

Stromal and epithelial TGF-β signaling in mammary tumorigenesis
por: Moses, HL, et al.
Publicado: (2005)

Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition
por: Moustakas, Aristidis, et al.
Publicado: (2016)

Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: three-dimensional organization and protein composition
Publicado: (1984)

Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation
por: Abreu, Maria Teresa Herrera, et al.
Publicado: (2011)

Lung Epithelial Injury by B. Anthracis Lethal Toxin Is Caused by MKK-Dependent Loss of Cytoskeletal Integrity
por: Lehmann, Mandy, et al.
Publicado: (2009)

Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association with Cell Shape and Cytoskeletal Modifications
por: Hagiyama, Man, et al.
Publicado: (2017)

Odorant Binding Causes Cytoskeletal Rearrangement, Leading to Detectable Changes in Endothelial and Epithelial Barrier Function and Micromotion
por: Curtis, Theresa M., et al.
Publicado: (2023)

TGF-β1 increases cellular invasion of colorectal neuroendocrine carcinoma cell line through partial epithelial-mesenchymal transition
por: Sasaki, Norihiko, et al.
Publicado: (2022)

Hypoxia Enhances Fusion of Oral Squamous Carcinoma Cells and Epithelial Cells Partly via the Epithelial–Mesenchymal Transition of Epithelial Cells
por: Huang, Chun-ming, et al.
Publicado: (2018)

IL-27 inhibits the TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells
por: Dong, Zhaoxing, et al.
Publicado: (2016)

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Proximal Tubular Epithelial Cells through miR-545-3p–TNFSF10
por: Kuo, Mei-Chuan, et al.
Publicado: (2021)

Measuring expression heterogeneity of single-cell cytoskeletal protein complexes
por: Vlassakis, Julea, et al.
Publicado: (2021)

Epithelial exposure to hypoxia modulates neutrophil transepithelial migration
Publicado: (1996)

Hypoxia Modulates Infection of Epithelial Cells by Pseudomonas aeruginosa
por: Schaible, Bettina, et al.
Publicado: (2013)

Hypoxia Increases Epithelial Permeability in Human Nasal Epithelia
por: Min, Hyun Jin, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_8i2hdk4kedhfjsv5e40cmlsppt