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Cyclosporines Antagonize the Antiviral Activity of IFITMProteins by Redistributing Them toward the Golgi Apparatus

Interferon-induced transmembrane proteins (IFITMs) block the fusion of diverse enveloped viruses, likely through increasing the cell membrane’s rigidity. Previous studies have reported that the antiviral activity of the IFITM family member, IFITM3, is antagonized by cell pretreatment with rapamycin...

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Detalles Bibliográficos
Autores principales: Prikryl, David, Marin, Mariana, Desai, Tanay M., Du, Yuhong, Fu, Haian, Melikyan, Gregory B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296495/
https://www.ncbi.nlm.nih.gov/pubmed/37371517
http://dx.doi.org/10.3390/biom13060937