How Do Cancer-Related Mutations Affect the Oligomerisation State of the p53 Tetramerisation Domain?

Tumour suppressor p53 plays a key role in the development of cancer and has therefore been widely studied in recent decades. While it is well known that p53 is biologically active as a tetramer, the tetramerisation mechanism is still not completely understood. p53 is mutated in nearly 50% of cancers...

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Detalles Bibliográficos
Autores principales: Nicolini, Federica, Todorovski, Toni, Puig, Eduard, Díaz-Lobo, Mireia, Vilaseca, Marta, García, Jesús, Andreu, David, Giralt, Ernest
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296842/
https://www.ncbi.nlm.nih.gov/pubmed/37367066
http://dx.doi.org/10.3390/cimb45060317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296842/
https://www.ncbi.nlm.nih.gov/pubmed/37367066
http://dx.doi.org/10.3390/cimb45060317

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