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How Do Cancer-Related Mutations Affect the Oligomerisation State of the p53 Tetramerisation Domain?
Tumour suppressor p53 plays a key role in the development of cancer and has therefore been widely studied in recent decades. While it is well known that p53 is biologically active as a tetramer, the tetramerisation mechanism is still not completely understood. p53 is mutated in nearly 50% of cancers...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296842/ https://www.ncbi.nlm.nih.gov/pubmed/37367066 http://dx.doi.org/10.3390/cimb45060317 |