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PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant

Over the past decade, Programmed Death-Ligand 1 (PD-L1) has emerged as a prominent target for cancer immunotherapies. However, its potential as an immunosuppressive therapy has been limited. In this review, we present the immunological basis of graft rejection and graft-versus-host disease (GVHD), f...

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Autores principales: Handelsman, Shane, Overbey, Juliana, Chen, Kevin, Lee, Justin, Haj, Delour, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296912/
https://www.ncbi.nlm.nih.gov/pubmed/37371079
http://dx.doi.org/10.3390/cells12121609
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author Handelsman, Shane
Overbey, Juliana
Chen, Kevin
Lee, Justin
Haj, Delour
Li, Yong
author_facet Handelsman, Shane
Overbey, Juliana
Chen, Kevin
Lee, Justin
Haj, Delour
Li, Yong
author_sort Handelsman, Shane
collection PubMed
description Over the past decade, Programmed Death-Ligand 1 (PD-L1) has emerged as a prominent target for cancer immunotherapies. However, its potential as an immunosuppressive therapy has been limited. In this review, we present the immunological basis of graft rejection and graft-versus-host disease (GVHD), followed by a summary of biologically relevant molecular interactions of both PD-L1 and Programmed Cell Death Protein 1 (PD-1). Finally, we present a translational perspective on how PD-L1 can interrupt alloreactive-driven processes to increase immune tolerance. Unlike most current therapies that block PD-L1 and/or its interaction with PD-1, this review focuses on how upregulation or reversed sequestration of this ligand may reduce autoimmunity, ameliorate GVHD, and enhance graft survival following organ transplant.
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spelling pubmed-102969122023-06-28 PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant Handelsman, Shane Overbey, Juliana Chen, Kevin Lee, Justin Haj, Delour Li, Yong Cells Review Over the past decade, Programmed Death-Ligand 1 (PD-L1) has emerged as a prominent target for cancer immunotherapies. However, its potential as an immunosuppressive therapy has been limited. In this review, we present the immunological basis of graft rejection and graft-versus-host disease (GVHD), followed by a summary of biologically relevant molecular interactions of both PD-L1 and Programmed Cell Death Protein 1 (PD-1). Finally, we present a translational perspective on how PD-L1 can interrupt alloreactive-driven processes to increase immune tolerance. Unlike most current therapies that block PD-L1 and/or its interaction with PD-1, this review focuses on how upregulation or reversed sequestration of this ligand may reduce autoimmunity, ameliorate GVHD, and enhance graft survival following organ transplant. MDPI 2023-06-12 /pmc/articles/PMC10296912/ /pubmed/37371079 http://dx.doi.org/10.3390/cells12121609 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Handelsman, Shane
Overbey, Juliana
Chen, Kevin
Lee, Justin
Haj, Delour
Li, Yong
PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant
title PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant
title_full PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant
title_fullStr PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant
title_full_unstemmed PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant
title_short PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant
title_sort pd-l1’s role in preventing alloreactive t cell responses following hematopoietic and organ transplant
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296912/
https://www.ncbi.nlm.nih.gov/pubmed/37371079
http://dx.doi.org/10.3390/cells12121609
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