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PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant
Over the past decade, Programmed Death-Ligand 1 (PD-L1) has emerged as a prominent target for cancer immunotherapies. However, its potential as an immunosuppressive therapy has been limited. In this review, we present the immunological basis of graft rejection and graft-versus-host disease (GVHD), f...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296912/ https://www.ncbi.nlm.nih.gov/pubmed/37371079 http://dx.doi.org/10.3390/cells12121609 |
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author | Handelsman, Shane Overbey, Juliana Chen, Kevin Lee, Justin Haj, Delour Li, Yong |
author_facet | Handelsman, Shane Overbey, Juliana Chen, Kevin Lee, Justin Haj, Delour Li, Yong |
author_sort | Handelsman, Shane |
collection | PubMed |
description | Over the past decade, Programmed Death-Ligand 1 (PD-L1) has emerged as a prominent target for cancer immunotherapies. However, its potential as an immunosuppressive therapy has been limited. In this review, we present the immunological basis of graft rejection and graft-versus-host disease (GVHD), followed by a summary of biologically relevant molecular interactions of both PD-L1 and Programmed Cell Death Protein 1 (PD-1). Finally, we present a translational perspective on how PD-L1 can interrupt alloreactive-driven processes to increase immune tolerance. Unlike most current therapies that block PD-L1 and/or its interaction with PD-1, this review focuses on how upregulation or reversed sequestration of this ligand may reduce autoimmunity, ameliorate GVHD, and enhance graft survival following organ transplant. |
format | Online Article Text |
id | pubmed-10296912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102969122023-06-28 PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant Handelsman, Shane Overbey, Juliana Chen, Kevin Lee, Justin Haj, Delour Li, Yong Cells Review Over the past decade, Programmed Death-Ligand 1 (PD-L1) has emerged as a prominent target for cancer immunotherapies. However, its potential as an immunosuppressive therapy has been limited. In this review, we present the immunological basis of graft rejection and graft-versus-host disease (GVHD), followed by a summary of biologically relevant molecular interactions of both PD-L1 and Programmed Cell Death Protein 1 (PD-1). Finally, we present a translational perspective on how PD-L1 can interrupt alloreactive-driven processes to increase immune tolerance. Unlike most current therapies that block PD-L1 and/or its interaction with PD-1, this review focuses on how upregulation or reversed sequestration of this ligand may reduce autoimmunity, ameliorate GVHD, and enhance graft survival following organ transplant. MDPI 2023-06-12 /pmc/articles/PMC10296912/ /pubmed/37371079 http://dx.doi.org/10.3390/cells12121609 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Handelsman, Shane Overbey, Juliana Chen, Kevin Lee, Justin Haj, Delour Li, Yong PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant |
title | PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant |
title_full | PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant |
title_fullStr | PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant |
title_full_unstemmed | PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant |
title_short | PD-L1’s Role in Preventing Alloreactive T Cell Responses Following Hematopoietic and Organ Transplant |
title_sort | pd-l1’s role in preventing alloreactive t cell responses following hematopoietic and organ transplant |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296912/ https://www.ncbi.nlm.nih.gov/pubmed/37371079 http://dx.doi.org/10.3390/cells12121609 |
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