Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer’s Disease

We developed a new method to isolate small extracellular vesicles (sEVs) from male and female wild-type and 5xFAD mouse brains to investigate the sex-specific functions of sEVs in Alzheimer’s disease (AD). A mass spectrometric analysis revealed that sEVs contained proteins critical for EV formation...

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Detalles Bibliográficos
Autores principales: Elsherbini, Ahmed, Zhu, Zhihui, Quadri, Zainuddin, Crivelli, Simone M., Ren, Xiaojia, Vekaria, Hemendra J., Tripathi, Priyanka, Zhang, Liping, Zhi, Wenbo, Bieberich, Erhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297289/
https://www.ncbi.nlm.nih.gov/pubmed/37371093
http://dx.doi.org/10.3390/cells12121623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297289/
https://www.ncbi.nlm.nih.gov/pubmed/37371093
http://dx.doi.org/10.3390/cells12121623

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