Generation of a Syngeneic Heterozygous ACVRL1((wt/mut)) Knockout iPS Cell Line for the In Vitro Study of HHT2-Associated Angiogenesis

Hereditary hemorrhagic telangiectasia (HHT) type 2 is an autosomal dominant disease in which one allele of the ACVRL1 gene is mutated. Patients exhibit disturbances in TGF-beta/BMP-dependent angiogenesis and, clinically, often present with severe nosebleeds as well as a reduced quality of life. The...

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Detalles Bibliográficos
Autores principales: Xiang-Tischhauser, Li, Bette, Michael, Rusche, Johanna R., Roth, Katrin, Kasahara, Norio, Stuck, Boris A., Bakowsky, Udo, Wartenberg, Maria, Sauer, Heinrich, Geisthoff, Urban W., Mandic, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297623/
https://www.ncbi.nlm.nih.gov/pubmed/37371070
http://dx.doi.org/10.3390/cells12121600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297623/
https://www.ncbi.nlm.nih.gov/pubmed/37371070
http://dx.doi.org/10.3390/cells12121600

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