Cargando…

Pressure Clamping During Ocular Perfusions Drives Nitric Oxide-Mediated Washout

PURPOSE: The aim of this study was to test the hypothesis that nitric oxide (NO) mediates a pressure-dependent, negative feedback loop that maintains conventional outflow homeostasis and thus IOP. If true, holding pressure during ocular perfusions will result in uncontrolled production of NO, hyper-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kelly, Ruth A., McDonnell, Fiona S., De Ieso, Michael L., Overby, Darryl R., Stamer, W. Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2023
Materias:	Physiology and Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297780/ https://www.ncbi.nlm.nih.gov/pubmed/37358489 http://dx.doi.org/10.1167/iovs.64.7.36

Ejemplares similares

IOP, IOP Transient Impulse, Ocular Perfusion Pressure, and Mean Arterial Pressure Relationships in Nonhuman Primates Instrumented With Telemetry
por: Markert, John E., et al.
Publicado: (2018)

Differences in Outflow Facility Between Angiographically Identified High- Versus Low-Flow Regions of the Conventional Outflow Pathways in Porcine Eyes
por: Strohmaier, Clemens A., et al.
Publicado: (2023)

Intra-Subject Variability and Diurnal Cycle of Ocular Perfusion Pressure as Characterized by Continuous Telemetry in Nonhuman Primates
por: Wilson, Katherine I., et al.
Publicado: (2020)

Downregulation of Retinal Connexin 43 in GFAP-Expressing Cells Modifies Vasoreactivity Induced by Perfusion Ocular Pressure Changes
por: Liu, Guodong, et al.
Publicado: (2021)

Shear Stress in Schlemm’s Canal as a Sensor of Intraocular Pressure
por: McDonnell, Fiona, et al.
Publicado: (2020)

VEGF as a Paracrine Regulator of Conventional Outflow Facility
por: Reina-Torres, Ester, et al.
Publicado: (2017)

Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia
por: De Ieso, Michael L., et al.
Publicado: (2020)

Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration
por: Wen, Joanne C., et al.
Publicado: (2017)

Measurement of Ocular Compliance Using iPerfusion
por: Sherwood, Joseph M., et al.
Publicado: (2019)

Trabodenoson, an Adenosine Mimetic With A(1) Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice
por: Li, Guorong, et al.
Publicado: (2018)

Cardiopulmonary Resuscitation of Asystolic Newborn Lambs Prior to Umbilical Cord Clamping; the Timing of Cord Clamping Matters!
por: Polglase, Graeme R., et al.
Publicado: (2020)

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure
por: Li, Guorong, et al.
Publicado: (2020)

NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFβ2-Induced Outflow in HTM/HSC Constructs
por: Bastia, Elena, et al.
Publicado: (2021)

Decreased Choroidal Blood Perfusion Induces Myopia in Guinea Pigs
por: Zhou, Xuan, et al.
Publicado: (2021)

Ocular and Systemic Diurnal Rhythms in Emmetropic and Myopic Adults
por: Burfield, Hannah J., et al.
Publicado: (2019)

Patch-Clamp Recordings of Action Potentials From Human Atrial Myocytes: Optimization Through Dynamic Clamp
por: Verkerk, Arie O., et al.
Publicado: (2021)

Ocular perfusion pressure and ocular blood flow in glaucoma
por: Cherecheanu, A Popa, et al.
Publicado: (2013)

Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs
por: Zhou, Xuan, et al.
Publicado: (2020)

Diurnal Curve of the Ocular Perfusion Pressure
por: Kanadani, Fabio N, et al.
Publicado: (2016)

Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells
por: Banerjee, Juni, et al.
Publicado: (2017)

Pathogenic Mechanism of Dry Eye–Induced Chronic Ocular Pain and a Mechanism-Based Therapeutic Approach
por: Tei, Yuto, et al.
Publicado: (2022)

Role of Arginase in Selective Impairment of Endothelium-Dependent Nitric Oxide Synthase-Mediated Dilation of Retinal Arterioles during Early Diabetes
por: Hein, Travis W., et al.
Publicado: (2020)

Therapeutic Effects of PPARα Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration
por: Qiu, Fangfang, et al.
Publicado: (2017)

Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated
por: Liu, Zhen, et al.
Publicado: (2021)

Anterior Segment Anatomy and Conventional Outflow Physiology of the Tree Shrew (Tupaia belangeri)
por: Jasien, Jessica V., et al.
Publicado: (2022)

Peptide‐Functionalized Fluorescent Particles for In Situ Detection of Nitric Oxide via Peroxynitrite‐Mediated Nitration
por: Chang, Jason Y. H., et al.
Publicado: (2017)

The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes
por: Ge, Pei, et al.
Publicado: (2016)

Weighing in Ocular Perfusion Pressure in Managing Glaucoma
por: Topouzis, Fotis, et al.
Publicado: (2009)

Role of nitric oxide in optic nerve head blood flow regulation while experimental increase of ocular perfusion pressure
por: Told, Reinhard, et al.
Publicado: (2011)

Patch-Clamp Analysis of the Mitochondrial H(+) Leak in Brown and Beige Fat
por: Bertholet, Ambre M., et al.
Publicado: (2020)

Exploring the Coordination of Cardiac Ion Channels With Action Potential Clamp Technique
por: Horváth, Balázs, et al.
Publicado: (2022)

Nitric Oxide and Decreases in Resistance Exercise Blood Pressure With Aerobic Exercise Training in Older Individuals
por: Otsuki, Takeshi, et al.
Publicado: (2019)

Effect of interscalene block on intraocular pressure and ocular perfusion pressure
por: Basaran, Betul, et al.
Publicado: (2017)

Acute nitric oxide synthase inhibition and endothelin-1-dependent arterial pressure elevation
por: Rapoport, Robert M.
Publicado: (2014)

Arterial pressure variations as parameters of brain perfusion in response to central blood volume depletion and repletion
por: Bronzwaer, Anne-Sophie G. T., et al.
Publicado: (2014)

Effect of intracranial pressure on photoplethysmographic waveform in different cerebral perfusion territories: A computational study
por: Liu, Haipeng, et al.
Publicado: (2023)

Regulation of arterial pressure by the paraventricular nucleus in conscious rats: interactions among glutamate, GABA, and nitric oxide
por: Martins-Pinge, Marli C., et al.
Publicado: (2013)

Static and Dynamic Measurements of Compliance and Driving Pressure: A Pilot Study
por: Tawfik, Pierre, et al.
Publicado: (2022)

Voltage Clamp Studies on Internally Perfused Axons
por: Moore, J. W.
Publicado: (1965)

A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of I(k1) Ion Channels in Real-Time
por: Goversen, Birgit, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dc4auu12bqddbr3shr1rora25k