Incorporation of N7-Platinated Guanines into Thermus Aquaticus (Taq) DNA Polymerase: Atomistic Insights from Molecular Dynamics Simulations

In this work, we elucidated some key aspects of the mechanism of action of the cisplatin anticancer drug, cis-[Pt(NH(3))(2)Cl(2)], involving direct interactions with free nucleotides. A comprehensive in silico molecular modeling analysis was conducted to compare the interactions of Thermus aquaticus...

Descripción completa

Detalles Bibliográficos
Autores principales: De Castro, Federica, Ciardullo, Giada, Fanizzi, Francesco Paolo, Prejanò, Mario, Benedetti, Michele, Marino, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297917/
https://www.ncbi.nlm.nih.gov/pubmed/37372996
http://dx.doi.org/10.3390/ijms24129849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297917/
https://www.ncbi.nlm.nih.gov/pubmed/37372996
http://dx.doi.org/10.3390/ijms24129849

Ejemplares similares