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Incorporation of N7-Platinated Guanines into Thermus Aquaticus (Taq) DNA Polymerase: Atomistic Insights from Molecular Dynamics Simulations

In this work, we elucidated some key aspects of the mechanism of action of the cisplatin anticancer drug, cis-[Pt(NH(3))(2)Cl(2)], involving direct interactions with free nucleotides. A comprehensive in silico molecular modeling analysis was conducted to compare the interactions of Thermus aquaticus...

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Detalles Bibliográficos
Autores principales:	De Castro, Federica, Ciardullo, Giada, Fanizzi, Francesco Paolo, Prejanò, Mario, Benedetti, Michele, Marino, Tiziana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297917/ https://www.ncbi.nlm.nih.gov/pubmed/37372996 http://dx.doi.org/10.3390/ijms24129849

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