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Single-Molecule Telomere Assay via Optical Mapping (SMTA-OM) Can Potentially Define the ALT Positivity of Cancer

Telomeres play an essential role in protecting the ends of linear chromosomes and maintaining the integrity of the human genome. One of the key hallmarks of cancers is their replicative immortality. As many as 85–90% of cancers activate the expression of telomerase (TEL+) as the telomere maintenance...

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Detalles Bibliográficos
Autores principales: Raseley, Kaitlin, Jinwala, Zeal, Zhang, Dong, Xiao, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297966/
https://www.ncbi.nlm.nih.gov/pubmed/37372458
http://dx.doi.org/10.3390/genes14061278