Novel Vaccine against Pathological Pyroglutamate-Modified Amyloid Beta for Prevention of Alzheimer’s Disease

Post-translationally modified N-terminally truncated amyloid beta peptide with a cyclized form of glutamate at position 3 (pE(3)Aβ) is a highly pathogenic molecule with increased neurotoxicity and propensity for aggregation. In the brains of Alzheimer’s Disease (AD) cases, pE(3)Aβ represents a major...

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Detalles Bibliográficos
Autores principales: Zagorski, Karen, King, Olga, Hovakimyan, Armine, Petrushina, Irina, Antonyan, Tatevik, Chailyan, Gor, Ghazaryan, Manush, Hyrc, Krzysztof L., Chadarevian, Jean Paul, Davtyan, Hayk, Blurton-Jones, Mathew, Cribbs, David H., Agadjanyan, Michael G., Ghochikyan, Anahit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298272/
https://www.ncbi.nlm.nih.gov/pubmed/37372944
http://dx.doi.org/10.3390/ijms24129797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298272/
https://www.ncbi.nlm.nih.gov/pubmed/37372944
http://dx.doi.org/10.3390/ijms24129797

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