Glucosylceramide Synthase Inhibitors Induce Ceramide Accumulation and Sensitize H3K27 Mutant Diffuse Midline Glioma to Irradiation

H3K27M mutant (mut) diffuse midline glioma (DMG) is a lethal cancer with no effective cure. The glycosphingolipids (GSL) metabolism is altered in these tumors and could be exploited to develop new therapies. We tested the effect of the glucosylceramide synthase inhibitors (GSI) miglustat and eliglus...

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Detalles Bibliográficos
Autores principales: El Malki, Khalifa, Wehling, Pia, Alt, Francesca, Sandhoff, Roger, Zahnreich, Sebastian, Ustjanzew, Arsenij, Wilzius, Carolin, Brockmann, Marc A., Wingerter, Arthur, Russo, Alexandra, Beck, Olaf, Sommer, Clemens, Ottenhausen, Malte, Frauenknecht, Katrin B. M., Paret, Claudia, Faber, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298524/
https://www.ncbi.nlm.nih.gov/pubmed/37373053
http://dx.doi.org/10.3390/ijms24129905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298524/
https://www.ncbi.nlm.nih.gov/pubmed/37373053
http://dx.doi.org/10.3390/ijms24129905

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