Lysophosphatidic Acid Induces Podocyte Pyroptosis in Diabetic Nephropathy by an Increase of Egr1 Expression via Downregulation of EzH2

Podocyte damage and renal inflammation are the main features and pathogenesis of diabetic nephropathy (DN). Inhibition of lysophosphatidic acid (LPA) receptor 1 (LPAR1) suppresses glomerular inflammation and improves DN. Herein, we investigated LPA-induced podocyte damage and its underlying mechanis...

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Detalles Bibliográficos
Autores principales: Kim, Donghee, Ban, Ka-Yun, Lee, Geon-Ho, Jun, Hee-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298531/
https://www.ncbi.nlm.nih.gov/pubmed/37373116
http://dx.doi.org/10.3390/ijms24129968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298531/
https://www.ncbi.nlm.nih.gov/pubmed/37373116
http://dx.doi.org/10.3390/ijms24129968

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