Cargando…

Lysophosphatidic Acid Induces Podocyte Pyroptosis in Diabetic Nephropathy by an Increase of Egr1 Expression via Downregulation of EzH2

Podocyte damage and renal inflammation are the main features and pathogenesis of diabetic nephropathy (DN). Inhibition of lysophosphatidic acid (LPA) receptor 1 (LPAR1) suppresses glomerular inflammation and improves DN. Herein, we investigated LPA-induced podocyte damage and its underlying mechanis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Donghee, Ban, Ka-Yun, Lee, Geon-Ho, Jun, Hee-Sook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298531/ https://www.ncbi.nlm.nih.gov/pubmed/37373116 http://dx.doi.org/10.3390/ijms24129968

Ejemplares similares

Lysophosphatidic Acid Signaling in Diabetic Nephropathy
por: Lee, Jong Han, et al.
Publicado: (2019)

Lysophosphatidic Acid Promotes Epithelial–Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy
por: Lee, Geon-Ho, et al.
Publicado: (2022)

Treatment of Membranous Nephropathy by Disulfiram through Inhibition of Podocyte Pyroptosis
por: Lv, Daoyuan, et al.
Publicado: (2022)

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction
por: Wang, Hui, et al.
Publicado: (2022)

Lysophosphatidic acid increases mesangial cell proliferation in models of diabetic nephropathy via Rac1/MAPK/KLF5 signaling
por: Kim, Donghee, et al.
Publicado: (2019)

Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells
por: Kim, Donghee, et al.
Publicado: (2022)

Inhibition of lysophosphatidic acid receptor ameliorates Sjögren's syndrome in NOD mice
por: Park, Eunhye, et al.
Publicado: (2017)

GPR43 activation-mediated lipotoxicity contributes to podocyte injury in diabetic nephropathy by modulating the ERK/EGR1 pathway
por: Lu, Jian, et al.
Publicado: (2022)

Breviscapine alleviates podocyte injury by inhibiting NF-κB/NLRP3-mediated pyroptosis in diabetic nephropathy
por: Sun, Linlin, et al.
Publicado: (2023)

Tacrolimus Protects Podocytes from Apoptosis via Downregulation of TRPC6 in Diabetic Nephropathy
por: Ma, Ruixia, et al.
Publicado: (2021)

Editorial: Podocyte Pathology and Nephropathy
por: Lewko, Barbara, et al.
Publicado: (2015)

EzMAP: Easy Microbiome Analysis Platform
por: Shanmugam, Gnanendra, et al.
Publicado: (2021)

Editorial: Podocyte Pathology and Nephropathy—An Update
por: Lehtonen, Sanna, et al.
Publicado: (2019)

Epigenetic Alterations in Podocytes in Diabetic Nephropathy
por: Sugita, Erina, et al.
Publicado: (2021)

Podocyte puzzle: IgA nephropathy
por: Bharati, Joyita, et al.
Publicado: (2023)

Podocytes … What’s Under Yours? (Podocytes and Foot Processes and How They Change in Nephropathy)
por: Neal, Chris R.
Publicado: (2015)

Inhibition of Ceramide Accumulation in Podocytes by Myriocin Prevents Diabetic Nephropathy
por: Woo, Chang-Yun, et al.
Publicado: (2020)

Podocyte Pathology and Nephropathy – Sphingolipids in Glomerular Diseases
por: Merscher, Sandra, et al.
Publicado: (2014)

Metadherin facilitates podocyte apoptosis in diabetic nephropathy
por: Liu, Wen-Ting, et al.
Publicado: (2016)

MicroRNAs in Podocyte Injury in Diabetic Nephropathy
por: Ishii, Hiroki, et al.
Publicado: (2020)

MicroRNAs for podocyte injury in diabetic nephropathy
por: Morishita, Yoshiyuki
Publicado: (2021)

Mechanisms of podocyte injury and implications for diabetic nephropathy
por: Barutta, Federica, et al.
Publicado: (2022)

IgA nephropathy with podocytic infolding glomerulopathy
por: Wang, Zhouyang, et al.
Publicado: (2023)

Abnormally glycosylated MUC1 establishes a positive feedback circuit of inflammatory cytokines, mediated by NF-κB p65 and EzH2, in colitis-associated cancer
por: Cascio, Sandra, et al.
Publicado: (2017)

Peroxidase expression is decreased by palmitate in cultured podocytes but increased in podocytes of advanced diabetic nephropathy
por: Lee, Eugene, et al.
Publicado: (2018)

Ez-Metastasizing: The Crucial Roles of Ezrin in Metastasis
por: Buenaventura, Rand Gabriel M., et al.
Publicado: (2023)

Drug Targets for Oxidative Podocyte Injury in Diabetic Nephropathy
por: Bhatti, Adnan Bashir, et al.
Publicado: (2015)

Increased mitochondrial fission of glomerular podocytes in diabetic nephropathy
por: Ma, Yiqiong, et al.
Publicado: (2019)

Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy
por: Dai, Haoran, et al.
Publicado: (2017)

Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy
por: Zhang, Lili, et al.
Publicado: (2020)

Podocyte ACE2 protects against diabetic nephropathy
por: Harris, Raymond C.
Publicado: (2012)

Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes
por: Li, Xueling, et al.
Publicado: (2020)

Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria
por: Audzeyenka, Irena, et al.
Publicado: (2021)

Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway
por: Kim, Donghee, et al.
Publicado: (2021)

Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy
por: Suk Kang, Jeong, et al.
Publicado: (2021)

REC8 inhibits EMT by downregulating EGR1 in gastric cancer cells
por: Zhao, Junhong, et al.
Publicado: (2018)

Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy
por: Hsu, Yu-Hsiang, et al.
Publicado: (2017)

NLRP3-mediated pyroptosis in diabetic nephropathy
por: Wan, Jiayi, et al.
Publicado: (2022)

Effect of Cordyceps sinensis and Tripterygium wilfordii polyglycosidium on podocytes in rats with diabetic nephropathy
por: HAO, LI, et al.
Publicado: (2014)

EzCatDB: the Enzyme Catalytic-mechanism Database
por: Nagano, Nozomi
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_vbalqhj4buqavf26tieqbvhcqm