A Novel Bioactive Peptide, T14, Selectively Activates mTORC1 Signalling: Therapeutic Implications for Neurodegeneration and Other Rapamycin-Sensitive Applications

T14 modulates calcium influx via the α-7 nicotinic acetylcholine receptor to regulate cell growth. Inappropriate triggering of this process has been implicated in Alzheimer’s disease (AD) and cancer, whereas T14 blockade has proven therapeutic potential in in vitro, ex vivo and in vivo models of the...

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Detalles Bibliográficos
Autores principales: Ranglani, Sanskar, Ashton, Anna, Mahfooz, Kashif, Komorowska, Joanna, Graur, Alexandru, Kabbani, Nadine, Garcia-Rates, Sara, Greenfield, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298579/
https://www.ncbi.nlm.nih.gov/pubmed/37373106
http://dx.doi.org/10.3390/ijms24129961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298579/
https://www.ncbi.nlm.nih.gov/pubmed/37373106
http://dx.doi.org/10.3390/ijms24129961

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