β-Lapachone Exerts Anticancer Effects by Downregulating p53, Lys-Acetylated Proteins, TrkA, p38 MAPK, SOD1, Caspase-2, CD44 and NPM in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells

β-lapachone (β-Lap), a topoisomerase inhibitor, is a naturally occurring ortho-naphthoquinone phytochemical and is involved in drug resistance mechanisms. Oxaliplatin (OxPt) is a commonly used chemotherapeutic drug for metastatic colorectal cancer, and OxPt-induced drug resistance remains to be solv...

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Detalles Bibliográficos
Autores principales: Jung, Eun Joo, Kim, Hye Jung, Shin, Sung Chul, Kim, Gon Sup, Jung, Jin-Myung, Hong, Soon Chan, Kim, Choong Won, Lee, Won Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298581/
https://www.ncbi.nlm.nih.gov/pubmed/37373014
http://dx.doi.org/10.3390/ijms24129867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298581/
https://www.ncbi.nlm.nih.gov/pubmed/37373014
http://dx.doi.org/10.3390/ijms24129867

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