Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities

The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid is used as the substrate. Tyr603Asp+His604Val double mutation in mouse arachidonic acid lipoxygenase 15b humanized the product pattern and an inverse mutagenesis strategy...

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Detalles Bibliográficos
Autores principales: Kakularam, Kumar R., Canyelles-Niño, Miquel, Chen, Xin, Lluch, José M., González-Lafont, Àngels, Kuhn, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298594/
https://www.ncbi.nlm.nih.gov/pubmed/37373195
http://dx.doi.org/10.3390/ijms241210046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298594/
https://www.ncbi.nlm.nih.gov/pubmed/37373195
http://dx.doi.org/10.3390/ijms241210046

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