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Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities
The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid is used as the substrate. Tyr603Asp+His604Val double mutation in mouse arachidonic acid lipoxygenase 15b humanized the product pattern and an inverse mutagenesis strategy...
Autores principales: | Kakularam, Kumar R., Canyelles-Niño, Miquel, Chen, Xin, Lluch, José M., González-Lafont, Àngels, Kuhn, Hartmut |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10298594/ https://www.ncbi.nlm.nih.gov/pubmed/37373195 http://dx.doi.org/10.3390/ijms241210046 |
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