Denosumab Attenuates Glucolipotoxicity-Induced β-Cell Dysfunction and Apoptosis by Attenuating RANK/RANKL Signals

Obesity is strongly associated with insulin sensitivity in type 2 diabetes (T2D), mainly because free fatty acids (FFAs) are released from excess fat tissue. Long-term exposure to high levels of FFAs and glucose leads to glucolipotoxicity, causing damage to pancreatic β-cells, thus accelerating the...

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Detalles Bibliográficos
Autores principales: Lin, Sheng-Chieh, Tsou, Sing-Hua, Kuo, Chien-Yin, Chen, Wei-Liang, Wu, Kuan-Wen, Lin, Chih-Li, Huang, Chien-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299032/
https://www.ncbi.nlm.nih.gov/pubmed/37373436
http://dx.doi.org/10.3390/ijms241210289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299032/
https://www.ncbi.nlm.nih.gov/pubmed/37373436
http://dx.doi.org/10.3390/ijms241210289

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