New Allosteric Modulators of AMPA Receptors: Synthesis and Study of Their Functional Activity by Radioligand-Receptor Binding Analysis

The synthetic approaches to three new AMPA receptor modulators—derivatives of 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.1(3,11)]tetradecane-4,8,12-trione—had been developed and all steps of synthesis were optimized. The structures of the compounds contain tricyclic cage and indane fragments necessary...

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Detalles Bibliográficos
Autores principales: Golubeva, Elena A., Lavrov, Mstislav I., Veremeeva, Polina N., Vyunova, Tatiana V., Shevchenko, Konstantin V., Topchiy, Maxim A., Asachenko, Andrey F., Palyulin, Vladimir A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299041/
https://www.ncbi.nlm.nih.gov/pubmed/37373440
http://dx.doi.org/10.3390/ijms241210293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299041/
https://www.ncbi.nlm.nih.gov/pubmed/37373440
http://dx.doi.org/10.3390/ijms241210293

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