Molecular and Functional Relevance of Na(V)1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model

In heart failure and atrial fibrillation, a persistent Na(+) current (I(NaL)) exerts detrimental effects on cellular electrophysiology and can induce arrhythmias. We have recently shown that Na(V)1.8 contributes to arrhythmogenesis by inducing a I(NaL). Genome-wide association studies indicate that...

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Detalles Bibliográficos
Autores principales: Hartmann, Nico, Knierim, Maria, Maurer, Wiebke, Dybkova, Nataliya, Hasenfuß, Gerd, Sossalla, Samuel, Streckfuss-Bömeke, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299073/
https://www.ncbi.nlm.nih.gov/pubmed/37373335
http://dx.doi.org/10.3390/ijms241210189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299073/
https://www.ncbi.nlm.nih.gov/pubmed/37373335
http://dx.doi.org/10.3390/ijms241210189

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