Identifying the Molecular Drivers of Pathogenic Aldehyde Dehydrogenase Missense Mutations in Cancer and Non-Cancer Diseases

Human aldehyde dehydrogenases (ALDHs) comprising 19 isoenzymes play a vital role on both endogenous and exogenous aldehyde metabolism. This NAD(P)-dependent catalytic process relies on the intact structural and functional activity of the cofactor binding, substrate interaction, and the oligomerizati...

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Detalles Bibliográficos
Autores principales: Jessen-Howard, Dana, Pan, Qisheng, Ascher, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299257/
https://www.ncbi.nlm.nih.gov/pubmed/37373306
http://dx.doi.org/10.3390/ijms241210157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299257/
https://www.ncbi.nlm.nih.gov/pubmed/37373306
http://dx.doi.org/10.3390/ijms241210157

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