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Posttranslational Modification of Human Cytochrome CYP4F11 by 4-Hydroxynonenal Impairs ω-Hydroxylation in Malaria Pigment Hemozoin-Fed Monocytes: The Role in Malaria Immunosuppression
Malaria is a frequent parasitic infection becomes life threatening due to the disequilibrated immune responses of the host. Avid phagocytosis of malarial pigment hemozoin (HZ) and HZ-containing Plasmodium parasites incapacitates monocyte functions by bioactive lipoperoxidation products 4-hydroxynone...
Autores principales: | Skorokhod, Oleksii, Triglione, Vincenzo, Barrera, Valentina, Di Nardo, Giovanna, Valente, Elena, Ulliers, Daniela, Schwarzer, Evelin, Gilardi, Gianfranco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299294/ https://www.ncbi.nlm.nih.gov/pubmed/37373382 http://dx.doi.org/10.3390/ijms241210232 |
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