A De Novo Designed Trimeric Metalloprotein as a Ni(p) Model of the Acetyl-CoA Synthase

We present a Ni(p) site model of acetyl coenzyme-A synthase (ACS) within a de novo-designed trimer peptide that self-assembles to produce a homoleptic Ni(Cys)(3) binding motif. Spectroscopic and kinetic studies of ligand binding demonstrate that Ni binding stabilizes the peptide assembly and produce...

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Detalles Bibliográficos
Autores principales: Selvan, Dhanashree, Chakraborty, Saumen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299331/
https://www.ncbi.nlm.nih.gov/pubmed/37373464
http://dx.doi.org/10.3390/ijms241210317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299331/
https://www.ncbi.nlm.nih.gov/pubmed/37373464
http://dx.doi.org/10.3390/ijms241210317

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