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A De Novo Designed Trimeric Metalloprotein as a Ni(p) Model of the Acetyl-CoA Synthase
We present a Ni(p) site model of acetyl coenzyme-A synthase (ACS) within a de novo-designed trimer peptide that self-assembles to produce a homoleptic Ni(Cys)(3) binding motif. Spectroscopic and kinetic studies of ligand binding demonstrate that Ni binding stabilizes the peptide assembly and produce...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299331/ https://www.ncbi.nlm.nih.gov/pubmed/37373464 http://dx.doi.org/10.3390/ijms241210317 |