Dual-Warhead Conjugate Based on Fibroblast Growth Factor 2 Dimer Loaded with α-Amanitin and Monomethyl Auristatin E Exhibits Superior Cytotoxicity towards Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1

Targeting fibroblast growth factor receptor 1 (FGFR1) is a promising therapeutic strategy for various cancers associated with alterations in the FGFR1 gene. In this study, we developed a highly cytotoxic bioconjugate based on fibroblast growth factor 2 (FGF2), which is a natural ligand of this recep...

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Detalles Bibliográficos
Autores principales: Nawrocka, Daria, Krzyscik, Mateusz Adam, Sluzalska, Katarzyna Dominika, Otlewski, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299504/
https://www.ncbi.nlm.nih.gov/pubmed/37373291
http://dx.doi.org/10.3390/ijms241210143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299504/
https://www.ncbi.nlm.nih.gov/pubmed/37373291
http://dx.doi.org/10.3390/ijms241210143

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