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Dual-Warhead Conjugate Based on Fibroblast Growth Factor 2 Dimer Loaded with α-Amanitin and Monomethyl Auristatin E Exhibits Superior Cytotoxicity towards Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1

Targeting fibroblast growth factor receptor 1 (FGFR1) is a promising therapeutic strategy for various cancers associated with alterations in the FGFR1 gene. In this study, we developed a highly cytotoxic bioconjugate based on fibroblast growth factor 2 (FGF2), which is a natural ligand of this recep...

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Detalles Bibliográficos
Autores principales:	Nawrocka, Daria, Krzyscik, Mateusz Adam, Sluzalska, Katarzyna Dominika, Otlewski, Jacek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299504/ https://www.ncbi.nlm.nih.gov/pubmed/37373291 http://dx.doi.org/10.3390/ijms241210143

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