7-Ketocholesterol Promotes Retinal Pigment Epithelium Senescence and Fibrosis of Choroidal Neovascularization via IQGAP1 Phosphorylation-Dependent Signaling

Accumulation of 7-ketocholesterol (7KC) occurs in age-related macular degeneration (AMD) and was found previously to promote fibrosis, an untreatable cause of vision loss, partly through induction of endothelial-mesenchymal transition. To address the hypothesis that 7KC causes mesenchymal transition...

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Detalles Bibliográficos
Autores principales: Wang, Haibo, Ramshekar, Aniket, Cung, Thaonhi, Wallace-Carrete, Chris, Zaugg, Chandler, Nguyen, Jasmine, Stoddard, Gregory J., Hartnett, M. Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299509/
https://www.ncbi.nlm.nih.gov/pubmed/37373423
http://dx.doi.org/10.3390/ijms241210276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299509/
https://www.ncbi.nlm.nih.gov/pubmed/37373423
http://dx.doi.org/10.3390/ijms241210276

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