A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams

The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This p...

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Autores principales: Aksenov, Alexander V., Aksenov, Dmitrii A., Kurenkov, Igor A., Leontiev, Alexander V., Aksenov, Nicolai A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299564/
https://www.ncbi.nlm.nih.gov/pubmed/37373361
http://dx.doi.org/10.3390/ijms241210213
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author Aksenov, Alexander V.
Aksenov, Dmitrii A.
Kurenkov, Igor A.
Leontiev, Alexander V.
Aksenov, Nicolai A.
author_facet Aksenov, Alexander V.
Aksenov, Dmitrii A.
Kurenkov, Igor A.
Leontiev, Alexander V.
Aksenov, Nicolai A.
author_sort Aksenov, Alexander V.
collection PubMed
description The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.
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spelling pubmed-102995642023-06-28 A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams Aksenov, Alexander V. Aksenov, Dmitrii A. Kurenkov, Igor A. Leontiev, Alexander V. Aksenov, Nicolai A. Int J Mol Sci Article The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry. MDPI 2023-06-16 /pmc/articles/PMC10299564/ /pubmed/37373361 http://dx.doi.org/10.3390/ijms241210213 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aksenov, Alexander V.
Aksenov, Dmitrii A.
Kurenkov, Igor A.
Leontiev, Alexander V.
Aksenov, Nicolai A.
A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams
title A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams
title_full A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams
title_fullStr A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams
title_full_unstemmed A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams
title_short A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams
title_sort new, convenient way to fully substituted α,β-unsaturated γ-hydroxy butyrolactams
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299564/
https://www.ncbi.nlm.nih.gov/pubmed/37373361
http://dx.doi.org/10.3390/ijms241210213
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