Pharmacokinetics, Safety, and Tolerability of Single-Dose Orally Administered Venglustat in Healthy Chinese Volunteers

BACKGROUND AND OBJECTIVE: Deficiencies of enzymes acting downstream of glucosylceramide synthase (GCS) can cause severe substrate accumulation. Venglustat is a small-molecule, brain-penetrant GCS inhibitor under investigation for multiple diseases involving pathogenic glycosphingolipid accumulation....

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Detalles Bibliográficos
Autores principales: Li, Yingxin, Li, Yang, Li, Li, Xue, Wei, Xin, Kong, Wang, Titi, Shi, Aixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299927/
https://www.ncbi.nlm.nih.gov/pubmed/37269489
http://dx.doi.org/10.1007/s40261-023-01275-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299927/
https://www.ncbi.nlm.nih.gov/pubmed/37269489
http://dx.doi.org/10.1007/s40261-023-01275-6

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