Bedaquiline- and clofazimine- selected Mycobacterium tuberculosis mutants: further insights on resistance driven largely by Rv0678

Drug-resistant tuberculosis is a serious global health threat. Bedaquiline (BDQ) is a relatively new core drug, targeting the respiratory chain in Mycobacterium tuberculosis (Mtb). While mutations in the BDQ target gene, atpE, are rare in clinical isolates, mutations in the Rv0678 gene, a transcript...

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Detalles Bibliográficos
Autores principales: Snobre, J., Villellas, M. C., Coeck, N., Mulders, W., Tzfadia, O., de Jong, B. C., Andries, K., Rigouts, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300004/
https://www.ncbi.nlm.nih.gov/pubmed/37369740
http://dx.doi.org/10.1038/s41598-023-36955-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300004/
https://www.ncbi.nlm.nih.gov/pubmed/37369740
http://dx.doi.org/10.1038/s41598-023-36955-y

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