Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G

Mitochondrial (MT) dysfunction has been associated with several neurodegenerative diseases including Alzheimer’s disease (AD). While MT-copy number differences have been implicated in AD, the effect of MT heteroplasmy on AD has not been well characterized. Here, we analyzed over 1800 whole genome se...

Descripción completa

Detalles Bibliográficos
Autores principales: Smullen, Molly, Olson, Meagan N., Murray, Liam F., Suresh, Madhusoodhanan, Yan, Guang, Dawes, Pepper, Barton, Nathaniel J., Mason, Jivanna N., Zhang, Yucheng, Fernandez-Fontaine, Aria A., Church, George M., Mastroeni, Diego, Wang, Qi, Lim, Elaine T., Chan, Yingleong, Readhead, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300032/
https://www.ncbi.nlm.nih.gov/pubmed/37369829
http://dx.doi.org/10.1038/s41598-023-37541-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300032/
https://www.ncbi.nlm.nih.gov/pubmed/37369829
http://dx.doi.org/10.1038/s41598-023-37541-y

Ejemplares similares