Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G

Mitochondrial (MT) dysfunction has been associated with several neurodegenerative diseases including Alzheimer’s disease (AD). While MT-copy number differences have been implicated in AD, the effect of MT heteroplasmy on AD has not been well characterized. Here, we analyzed over 1800 whole genome se...

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Detalles Bibliográficos
Autores principales: Smullen, Molly, Olson, Meagan N., Murray, Liam F., Suresh, Madhusoodhanan, Yan, Guang, Dawes, Pepper, Barton, Nathaniel J., Mason, Jivanna N., Zhang, Yucheng, Fernandez-Fontaine, Aria A., Church, George M., Mastroeni, Diego, Wang, Qi, Lim, Elaine T., Chan, Yingleong, Readhead, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300032/
https://www.ncbi.nlm.nih.gov/pubmed/37369829
http://dx.doi.org/10.1038/s41598-023-37541-y

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