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Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1
Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory role of microglia in retinal angiogenesis has been explored, little is known about its role in pro-angiogenesis and the microglia–endothelia interaction. Here, w...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300109/ https://www.ncbi.nlm.nih.gov/pubmed/37369647 http://dx.doi.org/10.1038/s41419-023-05897-8 |
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author | Zhou, Zi-Yi Chang, Tian-Fang Lin, Zhi-Bin Jing, Yu-Tong Wen, Li-Shi Niu, Ya-Li Bai, Qian Guo, Chang-Mei Sun, Jia-Xing Wang, Yu-Sheng Dou, Guo-Rui |
author_facet | Zhou, Zi-Yi Chang, Tian-Fang Lin, Zhi-Bin Jing, Yu-Tong Wen, Li-Shi Niu, Ya-Li Bai, Qian Guo, Chang-Mei Sun, Jia-Xing Wang, Yu-Sheng Dou, Guo-Rui |
author_sort | Zhou, Zi-Yi |
collection | PubMed |
description | Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory role of microglia in retinal angiogenesis has been explored, little is known about its role in pro-angiogenesis and the microglia–endothelia interaction. Here, we report that galectin-3 (Gal3) released by activated microglia functions as a communicator between microglia and endothelia and competitively binds to Jag1, thus inhibiting the Notch signaling pathway and enhancing endothelial angiogenic metabolism to promote angiogenesis. These results suggest that Gal3 may be a novel and effective target in the treatment of retinal angiogenesis. |
format | Online Article Text |
id | pubmed-10300109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103001092023-06-29 Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1 Zhou, Zi-Yi Chang, Tian-Fang Lin, Zhi-Bin Jing, Yu-Tong Wen, Li-Shi Niu, Ya-Li Bai, Qian Guo, Chang-Mei Sun, Jia-Xing Wang, Yu-Sheng Dou, Guo-Rui Cell Death Dis Article Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory role of microglia in retinal angiogenesis has been explored, little is known about its role in pro-angiogenesis and the microglia–endothelia interaction. Here, we report that galectin-3 (Gal3) released by activated microglia functions as a communicator between microglia and endothelia and competitively binds to Jag1, thus inhibiting the Notch signaling pathway and enhancing endothelial angiogenic metabolism to promote angiogenesis. These results suggest that Gal3 may be a novel and effective target in the treatment of retinal angiogenesis. Nature Publishing Group UK 2023-06-28 /pmc/articles/PMC10300109/ /pubmed/37369647 http://dx.doi.org/10.1038/s41419-023-05897-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhou, Zi-Yi Chang, Tian-Fang Lin, Zhi-Bin Jing, Yu-Tong Wen, Li-Shi Niu, Ya-Li Bai, Qian Guo, Chang-Mei Sun, Jia-Xing Wang, Yu-Sheng Dou, Guo-Rui Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1 |
title | Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1 |
title_full | Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1 |
title_fullStr | Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1 |
title_full_unstemmed | Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1 |
title_short | Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1 |
title_sort | microglial galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via notch inhibition by competitively binding to jag1 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300109/ https://www.ncbi.nlm.nih.gov/pubmed/37369647 http://dx.doi.org/10.1038/s41419-023-05897-8 |
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