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Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1

Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory role of microglia in retinal angiogenesis has been explored, little is known about its role in pro-angiogenesis and the microglia–endothelia interaction. Here, w...

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Autores principales: Zhou, Zi-Yi, Chang, Tian-Fang, Lin, Zhi-Bin, Jing, Yu-Tong, Wen, Li-Shi, Niu, Ya-Li, Bai, Qian, Guo, Chang-Mei, Sun, Jia-Xing, Wang, Yu-Sheng, Dou, Guo-Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300109/
https://www.ncbi.nlm.nih.gov/pubmed/37369647
http://dx.doi.org/10.1038/s41419-023-05897-8
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author Zhou, Zi-Yi
Chang, Tian-Fang
Lin, Zhi-Bin
Jing, Yu-Tong
Wen, Li-Shi
Niu, Ya-Li
Bai, Qian
Guo, Chang-Mei
Sun, Jia-Xing
Wang, Yu-Sheng
Dou, Guo-Rui
author_facet Zhou, Zi-Yi
Chang, Tian-Fang
Lin, Zhi-Bin
Jing, Yu-Tong
Wen, Li-Shi
Niu, Ya-Li
Bai, Qian
Guo, Chang-Mei
Sun, Jia-Xing
Wang, Yu-Sheng
Dou, Guo-Rui
author_sort Zhou, Zi-Yi
collection PubMed
description Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory role of microglia in retinal angiogenesis has been explored, little is known about its role in pro-angiogenesis and the microglia–endothelia interaction. Here, we report that galectin-3 (Gal3) released by activated microglia functions as a communicator between microglia and endothelia and competitively binds to Jag1, thus inhibiting the Notch signaling pathway and enhancing endothelial angiogenic metabolism to promote angiogenesis. These results suggest that Gal3 may be a novel and effective target in the treatment of retinal angiogenesis.
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spelling pubmed-103001092023-06-29 Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1 Zhou, Zi-Yi Chang, Tian-Fang Lin, Zhi-Bin Jing, Yu-Tong Wen, Li-Shi Niu, Ya-Li Bai, Qian Guo, Chang-Mei Sun, Jia-Xing Wang, Yu-Sheng Dou, Guo-Rui Cell Death Dis Article Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory role of microglia in retinal angiogenesis has been explored, little is known about its role in pro-angiogenesis and the microglia–endothelia interaction. Here, we report that galectin-3 (Gal3) released by activated microglia functions as a communicator between microglia and endothelia and competitively binds to Jag1, thus inhibiting the Notch signaling pathway and enhancing endothelial angiogenic metabolism to promote angiogenesis. These results suggest that Gal3 may be a novel and effective target in the treatment of retinal angiogenesis. Nature Publishing Group UK 2023-06-28 /pmc/articles/PMC10300109/ /pubmed/37369647 http://dx.doi.org/10.1038/s41419-023-05897-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhou, Zi-Yi
Chang, Tian-Fang
Lin, Zhi-Bin
Jing, Yu-Tong
Wen, Li-Shi
Niu, Ya-Li
Bai, Qian
Guo, Chang-Mei
Sun, Jia-Xing
Wang, Yu-Sheng
Dou, Guo-Rui
Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1
title Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1
title_full Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1
title_fullStr Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1
title_full_unstemmed Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1
title_short Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1
title_sort microglial galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via notch inhibition by competitively binding to jag1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300109/
https://www.ncbi.nlm.nih.gov/pubmed/37369647
http://dx.doi.org/10.1038/s41419-023-05897-8
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