K235 acetylation couples with PSPC1 to regulate the m(6)A demethylation activity of ALKBH5 and tumorigenesis

N6-methyladenosine (m(6)A) modification plays important roles in bioprocesses and diseases. AlkB homolog 5 (ALKBH5) is one of two m(6)A demethylases. Here, we reveal that ALKBH5 is acetylated at lysine 235 (K235) by lysine acetyltransferase 8 and deacetylated by histone deacetylase 7. K235 acetylati...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xiao-Lan, Chen, Xin-Hui, Xu, Binwu, Chen, Min, Zhu, Song, Meng, Nan, Wang, Ji-Zhong, Zhu, Huifang, Chen, De, Liu, Jin-Bao, Yan, Guang-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300122/
https://www.ncbi.nlm.nih.gov/pubmed/37369679
http://dx.doi.org/10.1038/s41467-023-39414-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300122/
https://www.ncbi.nlm.nih.gov/pubmed/37369679
http://dx.doi.org/10.1038/s41467-023-39414-4

Ejemplares similares