Cargando…

Inhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a malignant tumor, frequently causing both intrahepatic and extrahepatic metastases. The overall prognosis of patients with metastatic HCC is poor. Recently, single-cell (sc) polarity is proved to be an innate feature of some tumor cells in liquid phase, and directl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jian, Guo, Yongjian, Zhang, Ruitian, Xu, Ye, Luo, Chengju, Wang, Rui, Xu, Shu, Wei, Libin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300155/ https://www.ncbi.nlm.nih.gov/pubmed/37369706 http://dx.doi.org/10.1038/s41419-023-05903-z

Ejemplares similares

TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease
por: Martín-Bórnez, Marta, et al.
Publicado: (2020)

YMO1 suppresses invasion and metastasis by inhibiting RhoC signaling and predicts favorable prognosis in hepatocellular carcinoma
por: Chang, Rui-Min, et al.
Publicado: (2016)

Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway
por: Sun, Heng, et al.
Publicado: (2022)

CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma
por: Yao, Jingyue, et al.
Publicado: (2021)

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca(2+)/CaMKII/Nrf2 signaling pathway
por: Lv, Zhongyang, et al.
Publicado: (2021)

TRPV Subfamily (TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) Gene and Protein Expression in Patients with Ulcerative Colitis
por: Toledo Mauriño, Joel J., et al.
Publicado: (2020)

Activation of PTEN by inhibition of TRPV4 suppresses colon cancer development
por: Liu, Xiaoyu, et al.
Publicado: (2019)

Tumor-suppressive miR-3650 inhibits tumor metastasis by directly targeting NFASC in hepatocellular carcinoma
por: Wu, Jian, et al.
Publicado: (2019)

Leukemia cells remodel marrow adipocytes via TRPV4-dependent lipolysis
por: Yang, Shaoxin, et al.
Publicado: (2019)

A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression
por: Chen, Haiyang, et al.
Publicado: (2015)

Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel
por: Zhang, Xu-Feng, et al.
Publicado: (2011)

Single Residues in the Outer Pore of TRPV1 and TRPV3 Have Temperature-Dependent Conformations
por: Kim, Sung Eun, et al.
Publicado: (2013)

Comparative Analysis of Single-Molecule Dynamics of TRPV1 and TRPV4 Channels in Living Cells
por: Kuwashima, Yutaro, et al.
Publicado: (2021)

RIPK4 Suppresses the Invasion and Metastasis of Hepatocellular Carcinoma by Inhibiting the Phosphorylation of STAT3
por: Li, Haoran, et al.
Publicado: (2021)

TRPV4 Plays a Role in Matrix Stiffness-Induced Macrophage Polarization
por: Dutta, Bidisha, et al.
Publicado: (2020)

TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye
por: Ryskamp, Daniel A., et al.
Publicado: (2016)

TRPV4 Promotes Metastasis in Melanoma by Regulating Cell Motility through Cytoskeletal Rearrangement
por: Huang, Shuai, et al.
Publicado: (2022)

SERPINA11 Inhibits Metastasis in Hepatocellular Carcinoma by Suppressing MEK/ERK Signaling Pathway
por: Song, Ye, et al.
Publicado: (2021)

MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets
por: Chen, Shu-peng, et al.
Publicado: (2015)

Suppression of In Vivo Neovascularization by the Loss of TRPV1 in Mouse Cornea
por: Tomoyose, Katsuo, et al.
Publicado: (2015)

Macrophage polarization-associated lnc-Ma301 interacts with caprin-1 to inhibit hepatocellular carcinoma metastasis through the Akt/Erk1 pathway
por: Luo, Hong-Lin, et al.
Publicado: (2021)

miR-885-5p suppresses hepatocellular carcinoma metastasis and inhibits Wnt/β-catenin signaling pathway
por: Zhang, Zhuhong, et al.
Publicado: (2016)

Carcinogenesis and Metastasis: Focus on TRPV1-Positive Neurons and Immune Cells
por: Erin, Nuray, et al.
Publicado: (2023)

Alterations in the microenvironment and the effects produced of TRPV5 in osteoporosis
por: Luo, Zhi-heng, et al.
Publicado: (2023)

The Emerging Influences of Alpha-Fetoprotein in the Tumorigenesis and Progression of Hepatocellular Carcinoma
por: Xu, Ye, et al.
Publicado: (2021)

Physiological and Pathological Role of TRPV1, TRPV2 and TRPV4 Channels in Heart
por: Gorbunov, Alexandr S., et al.
Publicado: (2019)

TRPV1 Blocking Alleviates Airway Inflammation and Remodeling in a Chronic Asthma Murine Model
por: Choi, Joon Young, et al.
Publicado: (2018)

Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling
por: Kameda, Takuya, et al.
Publicado: (2019)

Commensal bacteria-derived extracellular vesicles suppress ulcerative colitis through regulating the macrophages polarization and remodeling the gut microbiota
por: Liang, Liping, et al.
Publicado: (2022)

ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis
por: Wu, Baitong, et al.
Publicado: (2022)

The role of TRPV1 ion channels in the suppression of gastric cancer development
por: Gao, Nannan, et al.
Publicado: (2020)

TRPV4 blockade suppresses atrial fibrillation in sterile pericarditis rats
por: Liao, Jie, et al.
Publicado: (2020)

Regulatory Network of Two Tumor-Suppressive Noncoding RNAs Interferes with the Growth and Metastasis of Renal Cell Carcinoma
por: Zhou, Hui, et al.
Publicado: (2019)

Molecular mechanism of albumin in suppressing invasion and metastasis of hepatocellular carcinoma
por: Fu, Xiao, et al.
Publicado: (2021)

Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function
por: Wu, Shih-Ying, et al.
Publicado: (2020)

Single cell polarity in liquid phase facilitates tumour metastasis
por: Lorentzen, Anna, et al.
Publicado: (2018)

Probiotic lactic acid bacteria alleviate pediatric IBD and remodel gut microbiota by modulating macrophage polarization and suppressing epithelial apoptosis
por: Hua, Huiying, et al.
Publicado: (2023)

MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis
por: Wang, Yingmei, et al.
Publicado: (2016)

miR-876 Inhibits EMT and Liver Fibrosis via POSTN to Suppress Metastasis in Hepatocellular Carcinoma
por: Chen, Kai, et al.
Publicado: (2020)

Overexpression of HDAC6 suppresses tumor cell proliferation and metastasis by inhibition of the canonical Wnt/β-catenin signaling pathway in hepatocellular carcinoma
por: Yin, Zhusheng, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_h35od8t61lm8r4bg60htbim1no